AZFb microdeletions and oligozoospermia—which mechanisms?  

Oleh:

Soares, Ana Rita ; Costa, Paula ; Silva, Joaquina ; Sousa, Mario

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 04 (Apr. 2012), page 858-863.
Topik: AZFb deletions; AZFb+c deletions; azoospermia; DAZ; Y chromosome

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To characterize the deletion patterns and its breakpoints in oligozoospermic patients presenting AZFb and AZFc microdeletions and to understand the recombination mechanisms underlying these microdeletions. Design Case report. Setting Genetics Department of Faculty of Medicine of Porto, Porto, Portugal. Patient(s) Two men with severe oligozoospermia and two men with nonobstructive azoospermia identified as having different AZFb+c deletion patterns via Y chromosome microdeletion analysis. Intervention(s) Definition of microdeletions and the fine characterization of the respective breakpoints by sequence-tagged sites (STS) polymerase chain reaction (PCR) and single-nucleotide variant (SNV) PCR. Main Outcome Measure(s) Study of the fine structure of the Y-chromosome and discussion of the putative mechanisms involved in each microdeletion pattern. Result(s)

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