Estriol administration modulates luteinizing hormone secretion in women with functional hypothalamic amenorrhea  

Oleh:

Genazzani, Alessandro D. ; Meczekalski, Blazej ; Podfigurna-Stopa, Agnieszka ; Santagni, Susanna

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 02 (Feb. 2012), page 483-488.
Topik: Estriol; GnRH; Hypothalamic Amenorrhea; Instantaneous Secretory Rate; LH

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate the influence of estriol administration on the hypothalamus-pituitary function and gonadotropins secretion in patients affected by functional hypothalamic amenorrhea (FHA). Design Controlled clinical study. Setting Patients with FHA in a clinical research environment. Patient(s) Twelve hypogonadotropic patients affected by FHA. Intervention(s) Pulsatility study of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and a gonadotropin-releasing hormone (GnRH) test (10 µg in bolus) at baseline condition and after 8 weeks of therapy with 2 mg/day of estriol. Main Outcome Measure(s) Measurements of plasma LH, FSH, estradiol (E2), androstenedione (A), 17a-hydroxyprogesterone (17-OHP), cortisol, androstenedione (A), testosterone (T), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and insulin, and pulse detection. Result(s) After treatment, the FHA patients showed a statistically significant increase of LH plasma levels (from 0.7 ± 0.1 mIU/mL to 3.5 ± 0.3 mIU/mL) and a statistically significant increase of LH pulse amplitude with no changes in LH pulse frequency. In addition, the LH response to the GnRH bolus was a statistically significant increase. Conclusion(s) Estriol administration induced the increase of LH plasma levels in FHA and improved GnRH-induced LH secretion. These findings suggest that estriol administration modulates the neuroendocrine control of the hypothalamus-pituitary unit and induces the recovery of LH synthesis and secretion in hypogonadotropic patients with FHA.

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