Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study  

Oleh:

Lin, Eleanor ; McCabe, Elizabeth ; Newton-Cheh, Christopher ; Bloch, Kenneth

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 02 (Feb. 2012), page 489-493.
Topik: Testosterone; Natriuretic Peptides

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate whether testosterone administration alters natriuretic peptide levels in women. Design Three-month, double-blind, randomized, placebo-controlled study. Setting Clinical research center. Patient(s) Fifty-one women with hypoandrogenemia due to hypopituitarism. Intervention(s) Transdermal testosterone (300 µg daily) or placebo patch. Main Outcome Measure(s) N-Terminal pro–B-type natriuretic peptide (NT-proBNP) levels. Result(s) NT-proBNP levels decreased in the transdermal testosterone group compared with placebo over three months. The difference between groups remained significant after controlling for baseline age, systolic blood pressure, body mass index, and homeostasis model assessment of insulin resistance. Change in NT-proBNP over 3 months was inversely associated with change in free testosterone levels. Conclusion(s) Testosterone administration to women results in decreased natriuretic peptide levels, suggesting that testosterone may be an inverse regulator of the natriuretic peptide system.

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