The Influence of Five Monoamine Genes on Trajectories of Depressive Symptoms Across Adolescence and Young Adulthood  

Oleh:

Adkins, Daniel E. ; Daw, Jonathan K. ; McClay, Joseph L. ; Oord, Edwin J.C.G. Van Den

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 24 no. 1 (Feb. 2012), page 267-286.
Topik: Young Adulthood; Mono-amine Genes; Dopamine Receptor; Characterized; Psychopathology

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.22 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The influence of five mono-amine candidate genes on depressive symptom trajectories in adolescence and young adulthood were examined in the Add Health genetic sample. Results indicated that, for all respondents, carriers of the dopamine receptor D4 5-repeat allele were characterized by distinct depressive symptom trajectories across adolescence and early adulthood. Similarly, for males, individuals with the mono-amine oxidize A 3.5-repeat allele exhibited unique depressive symptom trajectories. Specifically, the trajectories of those with the dopamine receptor D4 5-repeat allele were characterized by rising levels in the transition to adulthood, while their peers were experiencing a normative drop in depressive symptom frequency. Conversely, males with the mono-amine oxidize A 3.5-repeat allele were shown to experience increased distress in late adolescence. An empirical method for examining a wide array of allelic combination's was employed, and false discovery rate methods were used to control the risk of false positives due to multiple testing. Special attention was given to thoroughly interrogate the robustness of the putative genetic effects. These results demonstrate the value of combining dynamic developmental perspectives with statistical genetic methods to optimize the search for genetic influences on psychopathology across the life course.

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