Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities  

Oleh:

Dang, Yujie ; Yingying Qin ; Tang, Rong ; Mu, Yulan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 02 (Feb. 2012), page 391-394.
Topik: Müllerian Duct Abnormalities; Single-Nucleotide Polymorphisms; Synonymous; WNT7A

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To search for WNT7A gene mutations in a cohort of 191 Chinese Han patients with müllerian duct abnormalities (MDAs). Design Phenotypic and mutational study. Setting University hospital. Patient(s) A total of 191 Chinese Han patients with MDAs and 192 healthy control individuals. Intervention(s) Genomic DNA extracted from blood samples, all coding regions amplified by polymerase chain reaction (PCR) then directly sequenced to screen variants. Main Outcome Measure(s) Not applicable. Result(s) The sequence analysis revealed one novel synonymous variant and three known single-nucleotide polymorphisms (SNPs). Conclusion(s) The results indicate that mutations in the coding sequence of WNT7A are not responsible for müllerian duct abnormalities in the Chinese population.

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