Interaction of Serotonin Transporter Linked Polymorphic Region and Childhood Neglect on Criminal Behavior and Substance Use For Males and Females  

Oleh:

Vaske, Jamie ; Newsome, Jamie ; Wright, John Paul

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 24 no. 1 (Feb. 2012), page 181-194.
Topik: Serotonin Transporter; Criminal Behavior; 5-HTTLPR; Childhood Neglect

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.22 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Childhood neglect has been cited as a risk factor for later substance abuse and criminal behavior. However, a large body of literature shows that a substantial percentage of neglected and abused individuals do not go on to abuse substances or engage in criminal behavior. The current study investigates whether a genetic variant (serotonin transporter linked polymorphic region [5-HTTLPR]) in the 5-hydroxytryptamine (5-HTT) gene moderates the effect of childhood neglect on alcohol use problems, marijuana use, and criminal behavior. Data from the National Longitudinal Study of Adolescent Health shows that 5-HTTLPR conditions the effect of neglect on marijuana use for females, but not for males. Findings also reveal a significant gene–environment correlation between 5-HTTLPR and neglect for females only. These results suggest that 5-HTTLPR is associated with an increased risk of neglect for females, and it also increases neglected females’ risk of abusing marijuana.

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