Human spermatozoal RNAs  

Oleh:

Hamatani, Toshio

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 02 (Feb. 2012), page 275-281.
Topik: Sperm; RNA; Mirna; Paramutation; Microarray

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To provide a focused review of the scientific literature pertaining to spermatozoal RNA. Design Review of the literature and appraisal of relevant articles. Setting Not applicable. Patient(s) Infertile male. Intervention(s) None. Main Outcome Measure(s) Spermatozoal RNAs as potential epigenetic modifiers in early embryo development and as clinical markers of male infertility. Result(s) The nucleus of mature spermatozoa contains a complex population of mRNAs and miRNAs despite its transcriptionally inert state. Conclusion(s) A specific set of functional RNAs are delivered into oocytes during fertilization and are thought to contribute extragenomically to early embryonic development. Even if spermatozoal RNAs is merely residual, it still has the potential to greatly improve the investigative and diagnostic potential of male infertility.

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