Prediction of human blastocyst development from morulas with delayed and/or incomplete compaction  

Oleh:

Ivec, Martin ; Kovacic, Borut ; Vlaisavljevic, Veljko

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 06 (Dec. 2011), page 1473-1478.
Topik: Morula grading; morphometric analysis; delayed compaction; blastocyst development; inner cell mass size

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To determine the influence of delayed compaction and fragmentation on the developmental capacity of morulas. Design Prospective study. Setting University IVF center. Patient(s) Intracytoplasmic sperm injection (ICSI) cycles with compact embryos on day 4 or day 5. Intervention(s) The embryos were divided into day 4 (n = 329) and day 5 (n = 256) morulas and graded I, II, or III, according to the percentage of fragmentation (<5%, 5%–20%, or >20%). The embryos were measured using Cronus3 software. Main Outcome Measurement(s) Blastocyst development rate, blastocoel expansion rate, and optimal blastocyst rate. In an optimal blastocyst: surface area, trophectoderm cell number, inner cell mass (ICM) surface area, ICM volume and ICM shape. Result(s) Day 4 morulas in classes I–III developed into optimal blastocysts in 57.4%, 50%, and 35.6% of the total, respectively, and day 5 morulas in classes I–III in 43.3%, 29.1%, and 13.6% of the total, respectively. A negative association was identified between the amount of morula fragmentation, the blastocyst ICM size, and the number of trophectoderm cells. A delay of 1 day in compaction was associated with a reduced ICM volume. Conclusion(s) The measurement of compaction timing and cytoplasmic loss in morulas assists in predicting their ability to develop into optimal blastocysts.

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