The Origin of Ovarian Cancer — Is It Getting Clearer?  

Oleh:

Birrer, Michael J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 363 no. 16 (Nov. 2010), page 1574-1575.
Topik: CANCER; Ovarian Cancer

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The association of endometriosis and ovarian cancer was first reported by Sampson in 1925.1 Transitional areas of endometriosis, ranging from benign to atypical, adjacent to ovarian cancer have been well documented.2 The risk of ovarian cancer among women with endometriosis is higher, by 30 to 40%, than among women without endometriosis. The vast majority of ovarian cancers associated with endometriosis are clear-cell or endometrioid carcinomas. The early development of ovarian cancer remains poorly defined. Historically, most attention has been focused on serous adenocarcinoma, the most common and lethal histologic type. These tumors have been thought to arise from the surface of the ovary or from inclusion cysts. Recent work has proposed an alternative hypothesis: that a subgroup of these tumors arises from the fallopian tube.3 Regardless of the site of origin, the loss or inactivation of the tumor-suppressor protein p53 and BRCA proteins are early and important events in the development of serous tumors. The origin of rarer carcinomas (clear-cell, endometrioid, or mucinous) is less well defined and is presumed to be the ovary or possibly other gynecologic precursor lesions. The initiating molecular events are also unclear and include a broader number of genes.

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