Reference Intervals for Plasma l-Arginine and the l-Arginine:Asymmetric Dimethylarginine Ratio in the Framingham Offspring Cohort  

Oleh:

Luneburg, Nicole ; Xanthakis, Vanessa ; Edzard, Schwedhelm ; Sullivan, Lisa M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 141 no. 12 (Dec. 2011), page 2186-2190 .
Topik: Nutrient Requirements; Optimal Nutrition

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

l-Arginine, as a precursor of NO synthesis, has attracted much scientific attention in recent years. Experimental mouse models suggest that l-arginine supplementation can retard, halt, or even reverse atherogenesis. In human studies, supplementation with l-arginine improved endothelium-dependent vasodilation. However, l-arginine levels are best interpreted in the context of levels of asymmetric dimethylarginine (ADMA), a competitive inhibitor of NO synthase. Thus, reference limits for circulating l-arginine and the l-arginine:ADMA ratio may help to determine the nutritional state of individuals at high cardiovascular risk in light of increased ADMA levels. We defined reference limits for plasma l-arginine in 1141 people and for the l-arginine:ADMA ratio in 1138 relatively healthy individuals from the Framingham Offspring Cohort. Plasma l-arginine and ADMA concentrations were determined by using a stable isotope-based LC-MS/MS method. The reference limits (2.5th and 97.5th percentiles) for plasma l-arginine were 41.0 µmol/L (95% CI = 39.5–42.5 µmol/L) and 114 µmol/L (95% CI = 112–115 µmol/L), whereas corresponding reference limits (2.5th and 97.5th percentiles) for the l-arginine:ADMA ratio were 74.3 µmol/L (95% CI = 71.1–77.3 µmol/L) and 225 µmol/L (95% CI = 222–228 µmol/L). Plasma l-arginine was positively associated with the estimated glomerular filtration rate (eGFR) and blood glucose levels, whereas the l-arginine:ADMA ratio was positively associated with eGFR and diastolic blood pressure but inversely associated with homocysteine and (log)C-reactive protein. We report reference levels for plasma l-arginine and for the l-arginine:ADMA ratio that may be helpful for evaluation of the effects of l-arginine supplementation in participants with an impaired l-arginine/NO pathway.

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