Vitamin E Deficiency Decreases Long-Chain PUFA in Zebrafish (Danio rerio)  

Oleh:

Lebold, Katie M. ; Jump, Donald B. ; Miller, Galen W. ; Wright, Charlotte L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 141 no. 12 (Dec. 2011), page 2113-2118 .
Topik: Biochemical; Molecular; Genetic Mechanisms

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

a-Tocopherol is a required, lipid-soluble antioxidant that protects PUFA. We hypothesized that a-tocopherol deficiency in zebrafish compromises PUFA status. Zebrafish were fed for 1 y either an a-tocopherol-sufficient (E+; 500 mg a-tocopherol/kg) or -deficient (E-; 1.1 mg a-tocopherol/kg) diet containing a-linolenic (ALA) and linoleic (LA) acids but without arachidonic acid (ARA), EPA, or DHA. Vitamin E deficiency in zebrafish decreased by ~20% (n-6) (P < 0.05) and (n-3) (P < 0.05) PUFA and increased the (n-6):(n-3) PUFA ratio (P < 0.05). In E- compared to E+ females, long chain-PUFA status was impaired, as assessed by a ~60% lower DHA:ALA ratio (P < 0.05) and a ~50% lower ARA:LA ratio (P < 0.05). fads2 (P < 0.05) and elovl2 (P < 0.05) mRNA expression was doubled in E- compared to E+ fish. Thus, inadequate vitamin E status led to a depletion of PUFA that may be a result of either or both increased lipid peroxidation and an impaired ability to synthesize sufficient PUFA, especially (n-3) PUFA.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali