Semen quality and fertility in adult long-term survivors of childhood acute lymphoblastic leukemia  

Oleh:

Jahnukainen, Kirsi ; Heikkinen, Risto ; Henriksson, Markus ; Cooper, Trevor G.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 04 (Oct. 2011), page 837-842.
Topik: Childhood acute lymphoblastic leukemia; fertility; semen quality; survivors

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To assess testicular function and its determinants in adult survivors of childhood acute lymphoblastic leukemia (ALL) at a median time of 20 years after ALL therapy. Design Prospective investigation. Setting University hospital. Patient(s) Fifty-one male long-term survivors and 56 age-matched controls (median age of survivors at ALL diagnosis was 5 years, range: 1 to 15 years, and at the study 29 years, range: 26 to 38 years). Intervention(s) None. Main Outcome Measure(s) Testicular size (mean value of both testicular volumes), serum hormone concentrations, semen quality, and number of children fathered correlated with ALL therapy. Result(s) Survivors treated with 0–10 g/m2 of cyclophosphamide had sperm quality and fertility rates comparable with those of controls, but the serum free-testosterone in the survivors treated with cyclophosphamide was lower than in controls (median: 213 pmol/L, range: 189–260 vs. 296 pmol/L, range: 242–338, respectively). Cranial irradiation without cyclophosphamide did not affect semen quality, fertility, or testosterone levels. None of the survivors of a high cumulative dose of cyclophosphamide (>20 g/m2) and testicular irradiation (10–24 Gy) had fathered a child. Testicular size was shown to be better than serum inhibin B in predicting nonazoospermic semen samples or fertility. Conclusion(s) Treatment of childhood ALL with 0–10 g/m2 of cyclophosphamide and cranial irradiation does not affect fertility or semen quality but may impair long-term Leydig cell function.

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