Plasma leptin and adiponectin levels in hormone replacement therapy and contraception: effects of different progestogens  

Oleh:

Di Carlo, Costantino ; Tommaselli, Giovanni A. ; De Rosa, Nicoletta ; Fabozzi, Annamaria

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 01 (Jul. 2011), page 214-219.
Topik: Leptin; adiponectin; drospirenone; hormone replacement therapy; combined oral contraceptives

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate the impact of hormone replacement therapy and oral contraceptives containing different progestogens on adiponectin and leptin serum levels. Design Prospective, longitudinal, semi-randomized study. Setting General gynecology clinic of a university hospital. Patient(s) Forty-five healthy postmenopausal and 45 healthy premenopausal women. Intervention(s) Thirty postmenopausal women were randomized to receive either drospirenone (DRSP) 2 mg + E2 1 mg (n = 15) or norethisterone acetate (NETA) 0.5 mg + E2 1 mg (n = 15). Thirty premenopausal women were randomized to receive either ethinilestradiol (EE) 0.020 mg + DRSP 3 mg (n = 15) or EE 0.020 mg + desogestrel 0.15 mg (n = 15). Furthermore, 15 postmenopausal and 15 premenopausal untreated women served as controls. Main Outcome Measure(s) Adiponectin and leptin serum levels before and after 6 months of hormonal therapy. Result(s) No significant differences in leptin levels were detected in any group after 6 months. Adiponectin levels were significantly reduced in the NETA + E2 group and increased in the EE + DRSP group, while remaining unmodified in all other groups. Conclusion(s) Hormone replacement therapy with NETA, but not with DRSP, decreases serum adiponectin levels. Oral contraceptives containing DRSP increase serum adiponectin levels.

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