Birth of a healthy infant after intracytoplasmic sperm injection using pentoxifylline-activated sperm from a patient with Kartagener’s syndrome  

Oleh:

Hattori, Hiromitsu ; Nakajo, Yukiko ; Ito, Chizuru ; Toyama, Yoshiro

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 07 (Jun. 2011), page 2431.e9-11.
Topik: Kartagener’s syndrome; immotile cilia; pentoxifylline; ICSI; vitrification

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To describe the delivery of a healthy female infant after intracytoplasmic sperm injection (ICSI) using pentoxifylline-activated sperm from a patient with Kartagener’s syndrome. Design Case report. Setting Private assisted reproductive technology clinic in Japan. Patient(s) A couple with male factor infertility due to Kartagener’s syndrome. Intervention(s) Intracytoplasmic sperm injection using ejaculated sperm activated by pentoxifylline. Main Outcome Measure(s) Semen characteristics, sperm ultrastructure, fertilization, pregnancy, and birth after ICSI. Result(s) The fertilization rate was 7 of 12 (58.3%), and the blastocyst formation rate was 4 of 7 (57.1%); all blastocysts were vitrified. After a single blastcyst transfer, a pregnancy ensued and progressed to term; a healthy female infant was delivered. Conclusion(s) With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener’s syndrome.

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