Ovarian hyperstimulation syndrome in a patient treated with tamoxifen for breast cancer  

Oleh:

Baigent, Amy ; Lashen, Hany

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 07 (Jun. 2011), page 2429.e5-e7.
Topik: OHSS; ovarian hyperstimulation syndrome; tamoxifen; breast cancer

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To report the management of a rare case of ovarian hyperstimulation syndrome (OHSS) induced by tamoxifen therapy for breast cancer in a 50-year-old woman. Design Case report. Setting Gynecology outpatient department of a university hospital. Patient(s) A 50-year-old premenopausal patient with a history of breast cancer was prescribed adjuvant treatment with tamoxifen. Intervention(s) Temporary discontinuation of tamoxifen therapy resolved symptoms, but resumption of tamoxifen caused a recurrence of symptoms. Surgical bilateral salpingo-oophrectomy was therefore performed. Main Outcome Measure(s) Resolution of symptoms of OHSS. Result(s) Bilateral salpingo-oophrectomy rendered the patient postmenopausal and enabled the commencement of the aromatase inhibitor anastrozole as an alternative adjuvant therapy for breast cancer. Conclusion(s) Tamoxifen-induced OHSS is rare. Furthermore, OHSS is very rare in the older female. OHSS usually resolves with temporary discontinuation of tamoxifen, however, the recurrence of symptoms when resuming tamoxifen is better treated with bilateral salpingo-oophorectomy to enable adjuvant treatment with anastrazole.

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