Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels  

Oleh:

Buyuk, Erkan ; Seifer, David B. ; Younger, Joshua ; Grazi, Richard V. ; Lieman, Harry J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 07 (Jun. 2011), page 2369-2372.
Topik: Anti-Müllerian hormone; ART; Müllerian inhibiting substance; diminished ovarian reserve; elevated FSH levels; ovarian response

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. Design Retrospective study. Setting Academic and academically affiliated assisted reproductive technology (ART) programs. Patient(s) Seventy-three women undergoing ART with elevated early follicular FSH levels. Intervention(s) None. Main Outcome Measure(s) Number of oocytes retrieved during ART cycle, number of day 3 embryos, and cycle cancellation and clinical pregnancy rates. Result(s) Random AMH levels were strongly correlated with the number of oocytes retrieved during an ART cycle among women with elevated FSH (r = 0.55). Women with elevated FSH who had a random serum AMH level of 0.6 ng/mL or higher had twice the number of oocytes retrieved (11 ± 1.3 vs. 5.6 ± 0.6), a greater number of day 3 embryos (5.7 ± 0.9 vs. 3 ± 0.5), and approximately a third of the cycle cancellation rate (14% vs. 41%) compared with women with a random serum AMH below 0.6 ng/mL. The clinical pregnancy rate was also higher among women with a random serum AMH =0.6 ng/mL (28% vs. 14%), however, the difference was not statistically significant. Conclusion(s) A random serum AMH level is useful in setting expectations for ART prognosis in women with elevated early follicular-phase serum FSH levels.

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