The Influence of Diabetes on the Relationship between N-terminal Pro-Btype Natriuretic Peptide and Body Mass Index  

Oleh:

Kim, B.H. ; Kim, I.J. ; Cho, K.I. ; Kim, S.M. ; Lee, HG ; Kim, T.I.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 05 (Sep. 2010), page 1737-1748.
Topik: Congestive Heart Failure; Obesity; Diabetes; Body Mass Index; B-Type Natriuretic Peptide
Fulltext: s19.pdf (355.33KB)

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Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This study evaluated the influence of diabetes on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and body mass index (BMI). Simultaneous NT-proBNP and echocardio graphic Doppler examinations were performed in 1117 patients with dyspnoea undergoing cardiac catheterization. Patients were divided into BMI = 25 kg/m2 (obese), 23 - 25 kg/m2 (overweight) and < 23 kg/m2 (non-obese) groups. In the 803 non-diabetic patients, mean plasma NT-proBNP levels in non-obese, overweight and obese patients showed a significant negative correlation with BMI (862.3 ± 228.8 pg/ml, 611.5 ± 149.7 pg/ml, 278.3 ± 172.5 pg/ml, respectively). In the 314 patients with diabetes, there was no correlation between BMI and NT-proBNP. This study demonstrated that obese patients had reduced concentrations of NT-proBNP compared with non-obese patients, despite having higher left ventricular filling pressures. NT-proBNP was not reduced in obese patients with diabetes. These results suggest that factors other than cardiac status impact on NT-proBNP concentration.

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