Trauma Scores and Neuron-specific Enolase, Cytokine and C-reactive Protein Levels as Predictors of Mortality in Patients with Blunt Head Trauma  

Oleh:

Sogut, O. ; Guloglu, C. ; Orak, M. ; Sayhan, M.B. ; Gokdemir, M.T.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 05 (Sep. 2010), page 1708-1720.
Topik: Blunt Head Trauma; Neuron-Specific Enolase; Cytokines; C-Reactive Protein; Glasgow Coma Scale; Revised Trauma Score
Fulltext: s16.pdf (175.69KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This study evaluated serum neuronspecific enolase (NSE), cytokine and high-sensitivity C-reactive-protein (hs-CRP) levels, along with the Glasgow Coma Scale (GCS) and Revised Trauma Score (RTS), as predictors of mortality in the early post-traumatic period, in 100 Turkish patients with blunt head trauma. Overall patient mortality was 27%. There was a significant association between age and mortality, and mortality was negatively correlated with GCS and RTS. Head injury severity (GCS) was significantly related to NSE, hs-CRP, interleukin (IL)-6, IL-8 and tumour necrosis factor (TNF)-a levels. Mortality correlated positively with IL-6, IL-8, TNF-a and hs-CRP levels. NSE, hs-CRP, IL-6, IL-8 and TNF-a levels were significantly higher in non-survivors compared with survivors. GCS score = 8, younger age and NSE levels were significant independent predictors of mortality. During the early post-traumatic period, NSE may be an objective alternative criterion to the GCS, in the management of patients with blunt head trauma.

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