Local Delivery of Recombinant Human Bone Morphogenetic Protein-2 Increases Axonal Regeneration and the Expression of Tau Protein after Facial Nerve Injury  

Oleh:

Wu, G. ; Zhu, L. ; Jin, T. ; Chen, L. ; Shao, L. ; Wang, Y. ; Liu, B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 05 (Sep. 2010), page 1682-1688.
Topik: BONE; Bone Morphogenetic Protein-2 (Bmp-2); Facial Nerve; Clamping Injury; Nerve Regeneration; Tau Protein; Image Analysis
Fulltext: s13.pdf (157.09KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This study explored the function and possible mechanism of bone morphogenetic protein-2 (BMP-2) in the healing of injured peripheral nerves in vivo. Rabbit facial nerves were injured by clamping and then treated with recombinant human BMP-2 (rhBMP-2) or phosphate-buffered saline (control) by injecting once during surgery and twice a day post-injury for 7 days. Facial nerve fragments within 5 mm of the clamping point were examined at different times post-surgery. Axon structures visualized by Bielschowsky staining were similar in experimental and control nerves 2 and 6 weeks post-injury. At 4 weeks post-injury, cross-section images of facial nerves showed that axons treated with rhBMP-2 were denser and thicker, and levels of tau protein were increased. It is concluded from these data that rhBMP-2 may affect injured facial nerve regeneration by inducing more neurons to return to embryonic patterns of tau gene expression.

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