ADP-ribosylation Factor Guanine Nucleotide-exchange Factor 2 (ARFGEF2): a New Potential Biomarker in Huntington's Disease  

Oleh:

Lovrecic, L. ; Slavkov, I. ; Dzeroski, S. ; Peterlin, B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 05 (Sep. 2010), page 1653-1662.
Topik: Huntington's Disease; Trinucleotide Repeat Diseases; Gene Expression; Biomarkers; Transcriptomics; Adp-Ribosylation Factors; Arfgef2
Fulltext: s10.pdf (202.84KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Microarray searches have revealed potential genetic biomarkers in a wide variety of human diseases. Identification of biomarkers for disease status is particularly important in chronic neurodegenerative diseases where brain tissue cannot be sampled. A previous study identified 12 genes from microarray analysis as associated with Huntington's disease, although the relationships had not been validated. We used new machine learning approaches to reanalyse those microarray data and to rank the identified potential genetic biomarkers. We then performed quantitative reverse transcription-polymerase chain reaction analysis on a subset of the candidate genes in blood samples from an independent cohort of 23 Huntington's disease patients and 23 healthy controls. Our highest ranked genes did not overlap with the 12 previously identified, but two were significantly up-regulated in the Huntington's disease group: ARFGEF2 and GOLGA8G. Little is known about the latter, but the former warrants further analysis as it is known to be associated with intracellular vesicular trafficking, disturbances of which characterize Huntington's disease.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali