Vitamin D intake and risk of cardiovascular disease in US men and women  

Oleh:

Sun, Qin ; Shi, Ling ; Rimm, Eric B. ; Giovannucci, Edward L. ; Frank B Hu ; Manson, JoAnn E. ; Rexrode, Kathryn M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 94 no. 02 (Aug. 2011), page 534-542 .
Topik: Nutritional Epidemiology; Public Health
Fulltext: Am J Clin Nutr-2011-Sun-534-42.pdf (106.6KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Although studies have linked vitamin D deficiency to an increased risk of cardiovascular disease (CVD), evidence regarding whether vitamin D intake from foods or supplements is prospectively associated with lower CVD risk in healthy humans is limited and inconclusive. Objective: The objective was to comprehensively evaluate the associations between both dietary and supplemental vitamin D and CVD risk. Design: In the Nurses’ Health Study (1984–2006) and the Health Professionals Follow-Up Study (1986–2006)—consisting of 74,272 women and 44,592 men, respectively, who were free of CVD and cancer at baseline—we prospectively examined the association between vitamin D intake and incident CVD. Results: Over a total of 2,280,324 person-years of follow-up, we identified 9886 incident cases of coronary heart disease and stroke. After multivariate adjustment for age and other CVD risk factors, a higher total vitamin D intake (from foods and supplements) was associated with a decreased risk of CVD in men but not in women; the relative risks (95% CIs) for a comparison of participants who met the Dietary Reference Intake of vitamin D (=600 IU/d) with participants whose vitamin D intake was <100 IU/d were 0.84 (0.72, 0.97; P for trend = 0.009) for men and 1.02 (0.89, 1.17; P for trend = 0.12) for women. Conclusions: These observations suggest that a higher intake of vitamin D is associated with a lower risk of CVD in men but not in women. Further research is needed to confirm these findings and to elucidate a biological basis for potential sex differences.

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