Long-term effects of iron and zinc supplementation during infancy on cognitive function at 9 y of age in northeast Thai children: a follow-up study  

Oleh:

Pongcharoen, Tippawan ; DiGirolamo, Ann M. ; Ramakrishnan, Usha ; Winichagoon, Pattanee ; Flores, Rafael ; Martorell, Reynaldo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 93 no. 03 (Mar. 2011), page 636-643 .
Topik: NUTRITION; Micronutrients for Child; Zinc Supplementation
Fulltext: Am J Clin Nutr-2011-Pongcharoen-636-43.pdf (92.09KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Iron and zinc are important micronutrients for child growth and development. One would expect that iron and zinc supplementation in infancy would affect long-term cognitive development and school achievement, but this has not been evaluated. Objective: We investigated the effect of iron or zinc supplementation or both during infancy on cognitive performance 8 y later. Design: A follow-up study was performed in 560 children aged 9 y or 92% of those who had participated in a randomized controlled trial involving 4 groups who received daily iron, zinc, iron plus zinc, or a placebo at 4–6 mo of age for 6 mo. Cognitive performance was assessed by using the Wechsler Intelligence Scale for Children–Third Edition (Thai version), the Raven's Colored Progressive Matrices (CPM), and school performance tests. General linear mixed models were used to assess long-term effects. Results: No significant differences in any of the outcomes at 9 y of age were observed at follow-up between the 4 groups. Mean intelligence quotients ranged across groups from 92.9 to 93.7 for full scale, 93.9–95.4 for verbal, and 93.1–94.0 for performance. The Raven's CPM score ranged from 21.4 to 22.4. Conclusion: Supplementation with iron or zinc or both during infancy does not lead to long-term cognitive improvement in 9-y-old children.

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