Vitamin D and breast cancer recurrence in the Women's Healthy Eating and Living (WHEL) Study  

Oleh:

Jacobs, Elizabeth T. ; Thomson, Cynthia A ; Flatt, Shirley W ; Al-Delaimy, Wael K. ; Hibler, Elizabeth A. ; Jones, Lovell A. ; LeRoy, Elizabeth C. ; Newman, Vicky A. ; Parker, Barbara A. ; Rock, Cheryl L

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 93 no. 01 (Jan. 2011), page 108-117.
Topik: CANCER; Breast Cancer; Women's Healthy Eating; Postmenopausal Status
Fulltext: Am J Clin Nutr-97_plugin-108.full.pdf (100.07KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: There is a paucity of research evaluating the relation between vitamin D and recurrence of breast cancer after treatment. Objective: This study was designed to evaluate the associations between circulating concentrations of 25-hydroxyvitamin D [25(OH)D] and dietary, supplemental, and total intake of vitamin D and recurrent or new breast cancer events within the Women's Healthy Eating and Living (WHEL) Study. Design: A prospective cohort study design (n = 3085) was used to evaluate the relation between dietary, supplemental, and total vitamin D intake and recurrent breast cancer, and a nested case-control study with 512 matched pairs was used for analysis of the association between 25(OH)D and breast cancer recurrence. Results: No relation between 25(OH)D and breast cancer recurrence was observed. Compared with women with serum concentrations of 25(OH)D =30 ng/mL, adjusted odds ratios (95% CI) for breast cancer recurrence were 1.14 (0.57, 2.31) for those with concentrations <10 ng/mL, 1.00 (0.68–1.48) for concentrations =10 and <20 ng/mL, and 1.05 (0.76, 1.47) for concentrations =20 and < 30 ng/mL. No significant associations were observed when analyses were stratified by pre- and postmenopausal status or for local, regional, or distant recurrence or death. Vitamin D intake was not related to breast cancer recurrence overall, although for premenopausal women there was a significant inverse association between dietary vitamin D intake and recurrence (P for trend = 0.02). Conclusion: These results do not provide support for a relation between concentrations of 25(OH)D after treatment and the recurrence of breast cancer.

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