Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial  

Oleh:

Braga, Taciana Duque ; da Silva, Giselia Alves Pontes ; de Lira, Pedro Israel Cabral ; de Carvalho Lima, Marilia

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 93 no. 01 (Jan. 2011), page 81-86 .
Topik: GROWTH; Necrotizing Enterocolitis; Inflammatory Response; Mucosal Barrier Function
Fulltext: Am J Clin Nutr-2011-Braga-81-6.pdf (87.63KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Probiotics are used for the prevention of necrotizing enterocolitis (NEC) because of their positive effects on intestinal motor function, modulation of inflammatory response, and mucosal barrier function. Objective: The objective was to assess whether the combined use of Lactobacillus casei and Bifidobacterium breve may prevent the occurrence of NEC stage =2 by the criteria of Bell in very-low-birth-weight preterm infants. Design: A double-blind, randomized, controlled clinical trial was conducted in 231 preterm infants weighing from 750 to 1499 g at birth. The intervention group was composed of 119 infants who received human milk with probiotic supplementation (B. breve and L. casei) and a control group of 112 infants who received human milk containing no probiotics. The primary outcome was the occurrence of NEC stage =2 as defined by Bell's modified criteria. Results: Four confirmed cases of NEC stage =2 by Bell's criteria occurred only in the control group. Conclusions: Oral supplementation of B. breve and L. casei reduced the occurrence of NEC (Bell's stage =2). It was considered that an improvement in intestinal motility might have contributed to this result. This trial was registered at www.isrctin.org as number 67165178 (International Standard Randomized Controlled Trial).

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