A low–glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent ...  

Oleh:

Solomon, Thomas PJ ; Haus, Jacob M ; Kelly, Karen R ; Cook, Marc D ; Filion, Julianne ; Rocco, Michael ; Kashyap, Sangeeta R. ; Watanabe, Richard M. ; Barkoukis, Hope ; Kirwan, John P.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 92 no. 06 (Dec. 2010), page 1359-1368 .
Topik: DIABETES; Glucose Metabolism; Insulin Secretion; Diabetes Risk Reduction
Fulltext: Am J Clin Nutr-2010-Solomon-1359-68.pdf (367.32KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: The optimal lifestyle intervention that reverses diabetes risk factors is not known. Objective: We examined the effect of a low–glycemic index (GI) diet and exercise intervention on glucose metabolism and insulin secretion in obese, prediabetic individuals. Design: Twenty-two participants [mean ± SEM age: 66 ± 1 y; body mass index (in kg/m2): 34.4 ± 0.8] underwent a 12-wk exercise-training intervention (1 h/d for 5 d/wk at ˜85% of maximum heart rate) while randomly assigned to receive either a low-GI diet (LoGIX; 40 ± 0.3 units) or a high-GI diet (HiGIX; 80 ± 0.6 units). Body composition (measured by using dual-energy X-ray absorptiometry and computed tomography), insulin sensitivity (measured with a hyperinsulinemic euglycemic clamp with [6,6-2H2]-glucose), and oral glucose–induced insulin and incretin hormone secretion were examined. Results: Both groups lost equal amounts of body weight (-8.8 ± 0.9%) and adiposity and showed similar improvements in peripheral tissue (+76.2 ± 14.9%) and hepatic insulin sensitivity (+27.1 ± 7.1%) (all P < 0.05). However, oral glucose–induced insulin secretion was reduced only in the LoGIX group (6.59 ± 0.86 nmol in the prestudy compared with 4.70 ± 0.67 nmol in the poststudy, P < 0.05), which was a change related to the suppressed postprandial response of glucose-dependent insulinotropic polypeptide. When corrected for changes in ß cell glucose exposure, changes in insulin secretion were attenuated in the LoGIX group but became significantly elevated in the HiGIX group. Conclusions: Although lifestyle-induced weight loss improves insulin resistance in prediabetic individuals, postprandial hyperinsulinemia is reduced only when a low-GI diet is consumed. In contrast, a high-GI diet impairs pancreatic ß cell and intestinal K cell function despite significant weight loss. These findings highlight the important role of the gut in mediating the effects of a low-GI diet on type 2 diabetes risk reduction.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali