The Effects of Dietary Food Fortified With Vitamin B4 On Lipid Profiles in Serum and LIver Tissue  

Oleh:

Buang, Yohanes

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Kesehatan vol. 14 no. 1 (Jun. 2010), page 1-4.
Topik: Cholesterol; High density Lipoprotein; Serum Lipid; Triglyceride; Vitamin B4

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM75.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The effects of dietary food fortified with vitamin B4 on lipid profiles in serum and liver tissue were studied. Rats were paired-fed a 0.25% vitamin B4 diet or a diet without vitamin B4 for 10 days. Serum lipid levels were mesured using enzyme assay kits. Lipids of liver tissue were extracted and the lipid contents were determined. A piece of liver was prepared to determine the activities of fatty acid synthase (FAS) and fatty acid ß-oxidation. The result showed that animals fed a food fortified with vitamin B4 had higher level of serum TG, PL, total cholesterol, and high density lipoprotein. Their increases were approximately by 74%, 20%, 27%, and 27%, respectively. The significant changes in liver lipid were only found in PL component. This treatment promoted FAS activity, but impaired the fatty acid ß-oxidation. In conclusion: Dietary food fortified with vitamin B4 indices hypertriglyceridemia and liver PL level.

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