Humoural Immune Responses to a Recombinant 16-kDa–38-kDa–ESAT-6 Mycobacterial Antigen in Tuberculosis  

Oleh:

L, Wu ; M, Zhang ; M, Sun ; Jia B. ; X, Wang

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 02 (Mar. 2011), page 514-521.
Topik: Tuberculosis; Mycobacterium Tuberculosis; Serodiagnosis; Recombinant Protein; Enzyme-Linked Immunosorbent Assay
Fulltext: 1613.pdf (128.83KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The present study investigated the diagnostic value of a recombinant 38-kDa–16-kDa–early secreted antigenic target of 6 kDa (ESAT-6) Mycobacterium tuberculosis (MTB) fusion antigen in 105 patients with tuberculosis (TB), 25 non-TB pulmonary disease patients and 20 healthy individuals. Its diagnostic value was compared with the commercially available enzyme-linked immunosorbent assay kit, the TB-directly observed therapy (DOT) kit. In the controls, the rate of positive antibody response to the TB-DOT kit was significantly higher than that of the recombinant antigen. The area under the receiver operating characteristic curve was 0.751, and the optimum sensitivity and specificity for detecting antibody responses to the recombinant antigen were 65.4% and 84.8%, respectively. The recombinant 38-kDa–16-kDa–ESAT-6 MTB antigen was more effective than the TB-DOT kit in distinguishing between TB patients and controls, and may be an optimal combination of antigens to provide a useful tool for the sensitive and specific diagnosis of patients with TB.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali