Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3+CD8+ T-Lymphocytes following Skin Transplantation in Mice  

Oleh:

YX, Zhou ; SM, Zhao ; N, Lu ; Yang XJ. ; Y, Zhang ; YJ, Li ; X, Zou

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 02 (Mar. 2011), page 480-487.
Topik: SKIN CARE; Skin Transplantation; Acute Graft Rejection; Major Histocompatibility Complex Class I; Cd3+Cd8+ T-Lymphocytes; Peripheral Blood; Protein; Flow Cytometry; Mouse Model
Fulltext: 1610.pdf (222.66KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This study investigated major histocompatibility complex class I (MHC-I) antigen expression on peripheral blood T-cells after transplantation to assess its potential as an early marker of acute graft rejection (AGR). Using a mouse model with or without immunosuppressive treatment, the expression of MHC-I antigens on CD3+CD8+ T-lymphocytes was assessed by flow cytometry following syngeneic graft (n = 138) or allograft (n = 138) skin transplantation. The occurrence of AGR was assessed by examining the degree of lymphocyte and monocyte infiltration in transplant biopsies. During AGR, expression of MHC-I antigens increased significantly compared with pre-transplant levels in the allograft group, even with immunosuppressive treatment. The highest expression of MHC-I antigens occurred 5 – 6 days before macroscopic rejection. These results suggest that expression of MHC-I antigens on peripheral blood CD3+CD8+ T-lymphocytes could be used as an early marker for predicting AGR.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali