Osteogenic Growth Peptide Accelerates Bone Healing During Distraction Osteogenesis in Rabbit Tibia  

Oleh:

Zhao, Z-Y ; L, Shao ; H-M, Zhao ; Zhong, Z-H ; J-Y, Liu ; C-G, Hao

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 02 (Mar. 2011), page 456-463.
Topik: Osteogenic Growth Peptide; Growth Factors; Distraction Osteogenesis; Rabbit Model; External Fixator; Biomechanical Strength
Fulltext: 1608.pdf (220.58KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Distraction osteogenesis is a valuable treatment method that allows limb lengthening or reconstruction of large bone defects. However, its major disadvantage is the long period required for the consolidation of a distraction callus. Osteogenic growth peptide (OGP) stimulates endochondral bone formation in fracture callus, but its capacity to promote regenerate ossification during distraction osteogenesis has not been evaluated. This study investigated whether intravenously administered OGP accelerated bone healing during distraction osteogenesis in 36 male New Zealand White rabbits, randomized into two groups. The treatment group received OGP (200 ng/kg body weight) in phosphate-buffered saline (PBS), intravenously, each day; the control group received PBS alone. A 15-mm lengthening of the right lower leg was performed using the method of Ilizarov. Evidence from biomechanical, histological and radiographic evaluations demonstrated that systemic OGP treatment promoted optimal new bone formation during distraction osteogenesis in this rabbit model.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali