Interleukin-18 and IL18 -607A/C and -137G/C Gene Polymorphisms in Patients with Penicillin Allergy  

Oleh:

L, Ming ; Q, Wen ; H-L, Qiao ; Dong, Z.M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 02 (Mar. 2011), page 388-398.
Topik: PENICILLIN; Antibiotics; Allergy; Single Nucleotide Polymorphisms; Interleukin-18
Fulltext: 1595.pdf (141.82KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This study investigated the association between polymorphisms (–607A/C and –137G/C) in the promoter region of the IL18 gene (which encodes interleukin [IL]-18) and serum levels of IL-18, using standard genotyping techniques (sequence specific primer–polymerase chain reaction) and an enzyme-linked immunosorbent assay, respectively, in patients allergic to penicillin. A higher frequency of A alleles and the AA genotype was found at position –607A/C in patients allergic to penicillin than in control subjects. For the –137G/C position, the C allele was more frequent in patients allergic to penicillin than in control subjects. Haplotype analysis showed that the –607A/–137C haplotype was more frequent in patients allergic to penicillin than in control subjects. The patients had a significantly higher serum IL-18 level than the control subjects. In conclusion, IL18 –607A/C and –137G/C promoter polymorphisms are associated with susceptibility to penicillin allergy. In particular, the –137G/C position appears to play an important role in IL18 expression.

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