Increased expression of tuberin in human uterine leiomyoma  

Oleh:

Lihua, Cui ; Yuanyuan, Ren ; Hao, Yin ; Yuebing, Wang ; Dong, Li ; Meng, Liu ; Yingjun, Zhu ; Wanjun, Lin ; Xiang, D. Tang ; Yu, Gui ; Xi-Long, Zheng

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 05 (Apr. 2011), page 1805-1808.
Topik: UTERINE; Tuberin; tuberous sclerosis complex-2; uterine leiomyoma; mammalian target of rapamycin (mTOR); smooth muscle

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Female Eker rats harboring an insertional deletion in one copy of the tuberous sclerosis complex 2 (Tsc2) gene develop uterine leiomyoma, but the underlying mechanism of human uterine leiomyoma is not completely understood. To examine whether down-regulation of tuberin, a TSC2 gene product, is present in human uterine leiomyoma, we analyzed leiomyoma and matched myometrium tissues from 22 Chinese patients with Western blotting and real-time polymerase chain reaction analyses, and found that the expression of tuberin was significantly increased in leiomyoma tissues compared with matched myometrium tissues with inhibition of both the mammalian target of rapacmycin pathway and mitogen-activated protein kinase pathways.

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