Follicle-stimulating hormone administered at the time of human chorionic gonadotropin trigger improves oocyte developmental competence in in vitro fertilization cycles: a randomized, double-blind, placebo-controlled trial  

Oleh:

Lamb, Julie D. ; Shehua, Shen ; McCulloch, Charles ; Liza, Jalalian ; Cedars, Marcelle I. ; Rosen, Mitchell P.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 05 (Apr. 2011), page 1655-1660.
Topik: FERTILITY; Fertilization; FSH; hCG trigger; ICSI fertilization; IVF; IVF fertilization; menstrual physiology; oocyte competence; RCT; randomized control trial

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To determine whether an additional follicle-stimulating hormone (FSH) bolus administered at the time of the human chorionic gonadotropin (hCG) trigger can improve the developmental competence of the oocyte. Design Randomized, double-blind, placebo-controlled, clinical trial. Setting Academic medical center. Patient(s) Women undergoing a long agonist suppression in vitro fertilization (IVF) protocol for treatment of infertility. Intervention(s) FSH bolus at time of hCG trigger versus placebo. Main Outcome Measure(s) Primary outcome; fertilization; secondary outcomes: oocyte recovery, implantation rate, and clinical and ongoing pregnancy/live birth rates. Result(s) A total of 188 women (mean age: 36.2 years; range: 25 to 40 years) were randomized. Fertilization (2PN/#oocyte) was statistically significantly improved in the treatment arm (63% vs. 55%) as was the likelihood of oocyte recovery (70% vs. 57%). There was no statistically significant difference in clinical pregnancy rate (56.8% vs. 46.2%) or ongoing/live birth rate (51.6% vs. 43.0%). Conclusion(s) Improvements in IVF success rates have largely been due to optimization of embryo culture and stimulation protocols; less attention has been directed toward methods to improve induction of final oocyte maturation. This was the first randomized, double-blind, placebo-controlled trial to modify the ovulation trigger to improve oocyte competence, as demonstrated by the statistically significant improvement in fertilization.

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