Multiplying recipients paired with oocyte donors optimizes the use of donated oocytes  

Oleh:

Ziegler, Dominique de ; Mouzon, Jacques de ; Fauque, Patricia ; Zanette, Marianna ; Marszalek, Anne ; Blanchet, Valérie ; Boissonas, Celine Chalas ; Wolf, Jean Philippe ; Chapron, Charles

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 05 (Apr. 2011), page 1633-1638.
Topik: Donor-egg ART; donor-egg IVF; oocyte quality; pregnancy rates

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To review donor-egg assisted reproductive technology (ART) activity using young fertile donors (<37 years of age) paired with multiple recipients. Design Age-matched cohort study. Setting Tertiary ART center at Cochin Hospital, Paris. Patient(s) A total of 125 oocyte donors and 361 age-matched control subjects. Donated oocytes were attributed to 163 different recipients undertaking 258 transfer cycles. Intervention(s) Donor-egg and regular ART. Main Outcome Measure(s) Controlled ovarian hyperstimulation (COH) outcome—oocytes provided—was compared in donors and control subjects. Clinical pregnancy (cPR), ongoing pregnancy (oPR), and implantation (IR) rates per transfer in recipients were compared with age-matched controls. IRs were analyzed in the various recipients as a function of the number of oocytes harvested. Result(s) COH outcome was similar in donors and control subjects. cPR (37.5%), oPR (28.4%), and IR (24.4%) were slightly but significantly lower in donor-egg recipients compared with control subjects (44.9%, 37.4%, and 31.8%, respectively). More embryos (average +2.06) were transfered fresh and fewer frozen. In recipients, IRs were independent from the number of oocytes received in the donor. Conclusion(s) Multiplying recipients paired with oocyte donors slightly lowered per-transfer outcome, but enabled more (average +2.06) embryos to be transfered fresh.

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