Randomized trial of leuprolide versus continuous oral contraceptives in the treatment of endometriosis-associated pelvic pain  

Oleh:

Guzick, David ; Li-Shan, Huang ; Broadman, Betsy A. ; Nealon, Maureen ; Hornstein, Mark D.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 05 (Apr. 2011), page 1568-1573.
Topik: ENDOMETRIOSIS; Pelvic pain; GnRH agonists; gonadotropin-releasing hormone agonist; oral contraceptives; randomized controlled trial

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To compare the efficacy of leuprolide and continuous oral contraceptives in the treatment of endometriosis-associated pain. Design Prospective, randomized, double-blind controlled trial. Setting Academic medical centers in Rochester, New York, and Boston, Massachusetts. Patient(s) Forty-seven women with endometriosis-associated pelvic pain. Intervention(s) Forty-eight weeks of either depot leuprolide, 11.25 mg IM every 12 weeks with hormonal add-back using norethindrone acetate 5 mg orally, daily; or a generic monophasic oral contraceptive (1 mg norethindrone + 35 mg ethinyl estradiol) given daily. Main Outcome Measure(s) Biberoglu and Behrman (B&B) pain scores, numerical rating scores (NRS), Beck Depression Inventory (BDI), and Index of Sexual Satisfaction (ISS). Result(s) Based on enrollment of 47 women randomized to continuous oral contraceptives and to leuprolide, there were statistically significant declines in B&B, NRS, and BDI scores from baseline in both groups. There were no significant differences, however, in the extent of reduction in these measures between the groups. Conclusion(s) Leuprolide and continuous oral contraceptives appear to be equally effective in the treatment of endometriosis-associated pelvic pain.

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