Protective effect of calcium folinate against methotrexate-induced endosalpinx damage in rats  

Oleh:

Xiao-Jun, Yang ; Yan-Ping, Chen ; Han-Chu, Wang ; Jing, Zhao ; Fei-Yun, Zheng

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 04 (Mar. 2011), page 1526-1530.
Topik: Methotrexate; calcium folinate; endosalpinx; morphology; immunohistochemistry; estrogen receptor; progesterone receptor

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The aim of this study was to evaluate the protective effect of calcium folinate (CF) applied in 10% of the methotrexate (MTX) dosage against morphologic and steroid-receptor damage induced by MTX in rat endosalpinx. The result indicated that endosalpingitis, the ultrastructural damage of endosalpinx, and a change in estrogen and P receptor expression induced by low- and high-dose MTX in endosalpinx can be reversed completely and partly (B1, B2) by combined treatment with CF, suggesting that CF combined with MTX protects against the side effects induced by MTX.

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