Hsp90b1 knockout targeted to male germline: a mouse model for globozoospermia  

Oleh:

Audouard, Christophe ; Christians, Elisabeth

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 04 (Mar. 2011), page 1475-1477.
Topik: Gp96; Grp94; endoplasmic reticulum; spermiogenesis; male infertility; mouse model; Vasa-Cre

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

To study the role of Hsp90b1, an endoplasmic chaperone, we have built a conditional knockout by crossing Hsp90b1flox/flox with the Vasa-Cre transgenic line. Spermatozoa deficient in Hsp90b1 could not naturally fertilize oocytes and exhibited large and globular heads with abnormal intermediate pieces, a phenotype reminiscent of human globozoospermia.

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