Detail Koleksi Efek Ekstrak Air Daun Kelor terhadap Kadar Malondialdehida (MDA) dan Kolesterol Total Pada Tikus dengan Diet Tinggi Kolesterol Bibliografi Author: Henrina, Joshua ; Wahyuningsih, Komang Ardi (Advisor); Hidayat, Jenny (Examiner) Topik: ANTIOXIDANT; cholesterol; aqueous extract; Moringa Oleifera; malondialdehyde; total cholesterol Bahasa: (ID )     Penerbit: Fakultas Kedokteran Unika Atma Jaya     Tempat Terbit: Jakarta Utara    Tahun Terbit: 2017     Jenis: Theses - Karya Tulis Ilmiah Kedokteran (KTI-FK) Fulltext: KTI Joshua Henrina (2014060172).pdf (20,67MB; 79 download) lampiran KTI Joshua Henrina (2014060172).pdf (1,46MB; 11 download) Ketersediaan Perpustakaan FK Nomor Panggil: KTI-FK-1342 Non-tandon: tidak ada Tandon: 1  Lihat Detail Induk Abstrak Background: Coronary heart disease (CHD) is the leading cause of mortality worldwide. Hypercholesterolemia is well known as one of the risk factors. The pathogenesis of CHD is athersoclerosis, which started with plaque formation by low density lipoprotein and oxidative stress. Oxidative stress increase malondialdehyde (MDA) levels by fatty acid membrane cell peroxidation. Moringa Oleifera is a plant that rich in flavaonoid, phenolic, alkaloid, and vitamins. These compounds act as antioxidants and have a hypocholesterolemic effect that can counteract the effects of hypercholesterolemia Methods: This experiment is post test only with control group design. Samples are male Sprague Dawley rats that are fed with high cholesterol diet and aqueous extract with 100mg/bw, 150mg/bw, and 200mg/bw dose for 21 days. Plasma MDA levels and total cholesterol levels are quantified with TBARS and CHOD PAP method respectively. Result: Compared to control, there were differences in mean total cholesterol levels by 12%, 15%, and 20% in groups that are given with aqueous extract but aren’t significant. Meanwhile, mean MDA levels differed significantly in groups that are given with 150 and 200mg/bw dose of extract (P<0,05), but not in 100mg/bw. Conclusion: Various dose of moringa oleifera aqueous leaf extract didn’t cause any significant difference in total cholesterol level, but at 150mg/bw and 200mg/bw, these extracts cause significant difference in plasma MDA levels. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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