Fixed versus flexible gonadotropin-releasing hormone antagonist administration in in vitro fertilization: a randomized controlled trial  

Oleh:

Kolibianakis, Efstratios M. ; Venetis, Christos A. ; Kalogeropoulou, Lydia ; Papanikolaou, Evangelos G. ; Tarlatzis, Basil C.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 02 (Feb. 2011), page 558-562 .
Topik: FERTILITY; Gonadotropin-releasing hormone antagonists; in vitro fertilization; luteinizing hormone surge

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate whether the incidence of luteinizing hormone (LH) rise is reduced by using a flexible compared with a fixed day-6 protocol of GnRH antagonist administration. Design Randomized controlled trial. Setting Tertiary university hospital. Patient(s) Patients undergoing in vitro fertilization (n = 146). Intervention(s) Ovarian stimulation was performed using recombinant FSH and GnRH antagonists. GnRH antagonist cetrorelix (0.25 mg/d) was started either on day 6 of stimulation (fixed group) or when LH was >10 IU/L, and/or a follicle with mean diameter >12 mm was present, and/or serum E2 was >150 pg/mL. Patient monitoring was initiated on day 3 of stimulation. Main Outcome Measure(s) Incidence of LH rise. Result(s) No statistically significant difference was observed between the flexible and fixed groups regarding the incidence of LH rise, which was lower in the flexible group (11.0% vs. 15.1%, difference -4.1%, 95% confidence interval -15.4% to +7.1%). No LH surges were observed in any of the patients studied. Conclusion(s) Flexible antagonist administration from day 3 onward does not appear to reduce the incidence of LH rises compared with fixed antagonist administration on day 6 of stimulation.

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