HIV-positive patients undertaking ART have longer infertility histories than age-matched control subjects  

Oleh:

Santulli, Pietro ; Gayet, Vanessa ; Fauque, Patricia ; Chopin, Nicolas ; Dulioust, Emmanuel ; Wolf, Jean Philippe ; Chapron, Charles ; Ziegler, Dominique de

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 02 (Feb. 2011), page 507-512.
Topik: INFERTILITY; ART; HIV; ICSI; IVF; infertility duration

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To review 5 years of assisted reproductive treatments (ART) provided to couples affected by human immunodeficiency virus (HIV). Design Age-matched cohort study. Setting University-based tertiary center. Patient(s) Couples in whom the male (n = 87), female (n = 57), or both (n = 17) partners were HIV infected. The first ART cycle was compared with three sets of age-matched control subjects (3-to-1) which included 261, 171, and 51 couples, respectively. Intervention(s) ART in HIV-infected couples and age-matched controls. Main Outcome Measure(s) Infertility duration and ART outcome. Result(s) When initiating ART, all three HIV-infected groups had longer infertility histories, computed from when conception was attempted or infertility diagnosed, compared with noninfected age-matched control subjects. Outcome, however, was not different when only the male or female partner was infected, though with a trend toward higher cancelation and lower pregnancy rates. When both partners were HIV infected, cancelation were higher and pregnancy rates lower (12% versus 41.2%), than in age-matched control subjects. Conclusion(s) Our data showed longer infertility histories in all HIV-infected couples when undertaking their first ART. Outcome, however, was not altered when only one partner—male or female—was HIV infected. Efforts should therefore aim at assuring that HIV-infected couples access ART as promptly as their noninfected counterparts.

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