Background : Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammation disease with multiple clinical manifestation. Early diagnosis for SLE can reduce the mortality number. A more specific, easy and readily available biomarker is needed to diagnose SLE. Neutrophil to Lymphocyte Ratio (NLR) as a systemic inflammation biomarker, can be chosen as an alternative in diagnosing patients with SLE. Increasing NLR indicates neutrophilic leukocytosis and lymphopenia.
Objective : To determine the NLR on SLE incidence in subjects diagnosed with SLE at Kramat 128 Hospital.
Methodology : This study was done in February 2017 – December 2017 at Kramat 128 Hospital. Using medical records of patients admitted in the hospital with consecutive sampling method. This study is a cross sectional comparative analytic study on 34 SLE samples with 34 Healthy samples (non-SLE).
Results : The median NLR value on SLE (5,10 (1,53-22,00)) is higher than non-SLE (1,53 (1,11 – 2,96)) with p <0,005. NLR has a significant role in determining SLE and non-SLE with 2,99 cut-off value, 82,35% sensitivity and 94,12% specificity. The positive predictive value is 93,33% and the negative predictive value is 80%. A subject is determined SLE positive if NLR = 2,99.
Conclusion : The NLR cut-off value on SLE patient at Kramat 128 Hospital is 2,99. NLR has a role in determining SLE and non-SLE. A further study is required in determining the relation between NLR and SLE. |