Intravenous albumin administration for the prevention of severe ovarian hyperstimulation syndrome: a systematic review and metaanalysis  

Oleh:

Venetis, Christos A. ; Kolibianakis, Efstratios M. ; Toulis, Konstantinos A. ; Goulis, Dimitrios G. ; Papadimas, Ioannis ; Tarlatzis, Basil C.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 01 (Jan. 2011), page 188-196.
Topik: Albumin; prevention; severe ovarian hyperstimulation syndrome; metaanalysis

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Objective To reappraise the currently available evidence, providing the answer to the following question: does intravenous albumin administration reduce the risk of severe ovarian hyperstimulation syndrome (OHSS) occurrence following ovarian stimulation with gonadotrophins and GnRH analogues for IVF in high-risk patients? Design Systematic review and metaanalysis. Setting University-based hospital. Intervention(s) Intravenous albumin administration in high-risk patients for prevention of severe OHSS occurrence. Main Outcome Measure(s) Severe OHSS occurrence. Result(s) Eight eligible randomized controlled trials were identified (n = 1,199 patients) that offered data for statistical pooling. No statistically significant difference in the occurrence of severe OHSS in patients who received intravenous albumin (n = 595) and those who did not (n = 604; odds ratio [OR], 0.80; 95% confidence interval [CI], 0.52–1.22) was detected. Moreover, no statistically significant differences were present regarding the probability of pregnancy (OR, 0.83; 95% CI, 0.64–1.07) and first trimester pregnancy loss (OR, 1.44; 95% CI, 0.73–2.85) between patients who received intravenous albumin and those who did not. Conclusion(s) Based on the currently best available evidence, intravenous albumin administration in high-risk patients does not appear to reduce the occurrence of severe OHSS. This finding should be considered when implementing strategies for severe OHSS prevention.

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