ß2-Adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern  

Oleh:

Bei, Sun ; Williams, Jonathan S ; Svetkey, Laura P ; Kolatkar, Nikheel S ; Conlin, Paul R

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 92 no. 02 (Aug. 2010), page 444-449.
Topik: Gene-nutrient interactions; plasma renin activity (PRA); Dietary Approaches to Stop Hypertension (DASH); renin-angiotensin-aldosterone system (RAAS); G46A polymorphism; blood pressure

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: ß2-Adrenergic receptor (ß2-AR) is a susceptibility locus for hypertension, and polymorphisms at this site relate to salt sensitivity and low plasma renin activity (PRA). The Dietary Approaches to Stop Hypertension (DASH) dietary pattern lowers blood pressure and appears to interact with the renin-angiotensin-aldosterone system (RAAS). Objective: We hypothesized that the DASH diet associates with increased RAAS activity, and genotype status at ß2-AR G46A modifies this response. Design: We genotyped participants in the DASH-Sodium study (n = 372) at ß2-AR G46A to determine the association with blood pressure, RAAS components, and consumption of the DASH diet. We used 2-way mixed linear regression and an additive model for all primary analyses. Results: Mean (±SEM) PRA was significantly higher in participants in the DASH group than in participants in the control group (0.68 ± 0.03 compared with 0.54 ± 0.03 ng · mL-1 · h-1, P = 0.002). Serum aldosterone, urinary aldosterone, and urinary potassium concentrations were also significantly higher in the DASH group (P < 0.01 for all). We observed significant gene-diet interactions for changes in systolic blood pressure (SBP) and concentrations of aldosterone and urinary potassium (P for interaction = 0.048, 0.017, and 0.001 for SBP and aldosterone and urinary potassium concentrations, respectively). There was an association between the A allele of ß2-AR G46A and greater blood pressure reduction and blunted aldosterone and PRA responses to the DASH diet. Conclusions: Our results indicate that the DASH diet lowers blood pressure and increases PRA and aldosterone concentrations. There is an association between the G46A polymorphism of ß2-AR and blood pressure and RAAS responses to the DASH diet, which suggests that ß2-AR may be a genetic modifier of DASH-diet responsiveness.

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