Suboptimal vitamin K status despite supplementation in children and young adults with cystic fibrosis  

Oleh:

Dougherty, Kelly A ; Schall, Joan I. ; Stallings, Virginia A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 92 no. 03 (Sep. 2010), page 660-667.
Topik: cystic fibrosis (CF); pancreatic insufficiency; vitamin K supplements.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: For children and adolescents with cystic fibrosis (CF) and pancreatic insufficiency, the efficacy of routine vitamin K supplementation to normalize vitamin K status remains unclear. Objective: This study examined and determined predictors of vitamin K status in subjects aged 8–25 y with CF and pancreatic insufficiency taking various vitamin K supplements. Design: In 97 subjects, serum 25-hydroxyvitamin D [25(OH)D], dietary intake, vitamin K supplement intake, and vitamin K statusmdashdetermined on the basis of the percentage of serum undercarboxylated osteocalcin (%ucOC; sufficient: lt 20%) and plasma proteins induced by vitamin K absence–factor II (PIVKA-II; n = 60; sufficient: le 2 mug/L)mdashwere assessed. The vitamin K supplementation groups were as follows: lt 150 mug/d (low; multivitamins or no supplement), 150–999 mug/d (middle; CF-specific vitamins), and ge 1000 mug/d (high; mephyton). %ucOC values were compared with 140 healthy subjects aged 6–21 y. Results: In subjects with CF, the median (range) %ucOC was 35% (3%, 76%) and the median (range) for PIVKA-II was 2 (0, 42) mu g/L. Subjects with CF had a higher %ucOC with low [45% (10%, 76%)] and medium [41% (3%, 66%)] supplement intakes but not with a high supplement intake [16% (4%, 72%)] compared with healthy subjects [23% (0%, 43%); both P lt 0.05]. Supplementation group for males and females and 25(OH)D and age for males were significant predictors of vitamin K status. Conclusions: Vitamin K status was often suboptimal despite routine supplementation. Only subjects taking high-dose vitamin K achieved a status similar to healthy subjects, and only the vitamin K supplementation dose predicted vitamin K status for males and females. These data suggest that higher doses of vitamin K are required.

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