Discovery of a novel biomarker in the urine in women with endometriosis  

Oleh:

Tokushige, Natsuko ; Markham, Robert ; Crossett, Ben ; Ahn, Seong B. ; Nelaturi, Vidya L. ; Khan, Alamgir ; Fraser, Ian S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 01 (Jan. 2011), page 46-49.
Topik: Biomarker; endometriosis; urine

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis.Design Laboratory study using human urine. Setting: University-based laboratory.Patient(s) Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis.Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.

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