Detail Cell-death-inducing DFFA-like effector B contributes to the assembly of hepatitis C virus (HCV) particles and interacts with HCV NS5A (from Scientific Reports, 2016, 6 (27778), 1-14) Bibliografi Author: Cai, Hua ; Yao, Wenxia ; Li, Leike ; Li, Xinlei ; Hu, Longbo ; Mai, Runming ; Peng, Tao Topik: HCV; HCV NS5A; Hepatitis - Cadangan Bahasa: (EN )     Tahun Terbit: 2016     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: srep27778.pdf (2.39MB; 0 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract Hepatitis C virus (HCV) uses components of the very-low-density lipoprotein (VLDL) pathway for assembly/release. We previously reported that hepatocyte nuclear factor 4a (HNF4a) participates in HCV assembly/release through downstream factors those participate in VLDL assembly/secretion. Celldeath-inducing DFFA-like effector B (CIDEB) is an important regulator of the VLDL pathway. CIDEB is required for entry of HCV particles from cell culture (HCVcc), but the effects of CIDEB on the post-entry steps of the HCV lifecycle are unclear. In the present study, we determined that CIDEB is required for HCV assembly in addition to HCVcc entry. Furthermore, CIDEB interacts with the HCV NS5A protein, and the N terminus of CIDEB and the domain I of NS5A are involved in this interaction. Moreover, CIDEB silencing impairs the association of apolipoprotein E (ApoE) with HCV particles. Interestingly, CIDEB is also required for the post-entry stages of the dengue virus (DENV) life cycle. Collectively, these results indicate that CIDEB is a new host factor that is involved in HCV assembly, presumably by interacting with viral protein, providing new insight into the exploitation of the VLDL regulator CIDEB by HCV. [hepatitis - cadangan] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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