Detail T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease (from Nature Structural & Molecular Biology 2014) Bibliografi Author: Petersen, Jan ; Montserrat, Veronica ; Mujico, Jorge R. ; Loh, Khai Lee ; Beringer, Dennis X. ; Lummel, Menno van ; Thompson, Allan ; Mearin, M. Louisa ; Schweizer, Joachim ; Kooy-Winkelaar, Yvonne ; Bergen, Jeroen van ; Drijfhout, Jan W. ; Kan, Wan-Ting ; Gruta, Nicole L. La ; Anderson, Robert P. ; Reid, Hugh H. ; Koning, Frits ; Rossjohn, Jamie Topik: T-cell receptor; HLA-DQ2-gliadin; Celiac disease; Seminar - Thesis lit Bahasa: (EN )     Tahun Terbit: 2014     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: petersen2014.pdf (5.92MB; 0 download) Abstract Celiac disease is a T cell-mediated disease induced by dietary gluten, a component of which is gliadin. 95% of individuals with celiac disease carry the HLA (human leukocyte antigen)-DQ2 locus. Here we determined the T-cell receptor (TCR) usage and fine specificity of patient-derived T-cell clones specific for two epitopes from wheat gliadin, DQ2.5-glia-(alpha)1a and DQ2.5-glia-(alpha)2. We determined the ternary structures of four distinct biased TCRs specific for those e[itoppes. All three TCRs specific for DQ2.5-glia-(alpha)2 docked centrally aove HLA-DQ2, which together with mutagenesis and affinity measurements provided a basis for the biased TCR usage. A non-germline encoded arginine residue within the CDR3(beta) loop acted as the lynchpin within this common docking footprint. Although the TCRs specific for DQ2.5-glia-(alpha)1a and DQ2.5-glia-(alpha)2 docked similarly, their interactions with the respective gliadin determinants differed markedly, therby providing a basis for epitope specificity. [seminar - thesis lit] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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