Detail Immunodominance of HLA-A2-Restricted Hepatitis C Virus-Specific CD8+ T Cell Responses is Linked to Naive-Precursor Frequency (from Journal of Virology 2011, 85 (10), 5232-5236) Bibliografi Author: Schmidt, Julia ; Neumann-Haefelin, Christoph ; Altay, Tayibe ; Gostick, Emma ; Price, David A. ; Lohmann, Volker ; Blum, Hubert E. ; Thimme, Robert Topik: HCV; Hepatitis C; Validation ref - 6 Bahasa: (EN )     Penerbit: American Society for Microbiology     Tempat Terbit: Washington, D.C.    Tahun Terbit: 2011     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: J. Virol.-2011-Schmidt-5232-6.pdf (1.37MB; 0 download) Abstract The impact of naïve-precursor frequency on human virus-specific CD8 T cell immunodominance is not well understood. Using a recently developed major histocompatibility complex (MHC) class I tetramer enrichment protocol, we found a conserved hierarchy and a >10-fold difference in naïve-precursor frequencies across three HLA-A2-restricted hepatitis C virus (HCV)-specific epitopes. Importantly, the NS31406 epitope with the highest naïve-precursor frequency in healthy donors was also the most frequently targeted epitope in a large cohort of chronically HCV-infected patients, both ex vivo and after in vitro stimulation. These results indicate for the first time that immunodominance in a human viral infection is linked to naïve-precursor frequency. [validation ref - 6] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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