Detail Association of Hepatitis C Virus-Specific CD8+ T Cells with Viral Clearance in Acute Hepatitis C (from The Journal of Infectious Diseases 2000, 181, 1528-1536) Bibliografi Author: Gruner, Norbert H. ; Gerlach, Tilman J. ; Jung, Maria-Christina ; Diepolder, Helmut M. ; Schirren, Carl Albrecht ; Schraut, Winfried W. ; Hoffmann, Robert ; Zachoval, Reinhart ; Santantonio, Teresa ; Cucchiarini, M. ; Cerny, Andreas ; Pape, Gerd R. Topik: HCV; Hepatitis C; Validation ref - 6 Bahasa: (EN )     Penerbit: Infectious Diseases Society of America     Tahun Terbit: 2000     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 181-5-1528.pdf (173.28KB; 0 download) Abstract CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the outcome of infection. Eighteen patients with acute hepatitis C and 19 normal donors were studied. Hepatitis C virus (HCV)–specific CD8+ T cells were identified in the enzyme-linked immunospot assay by their interferon-g (IFN-g) production after specific stimulation. The highest numbers of IFN-g–producing HCV-specific CD8+ T cells were found in patients with acute hepatitis C and a self-limited course of disease during the first 6 months after onset of disease, but these numbers dropped thereafter to undetectable levels. The differences in responsiveness between patients with self-limited disease versus patients with a chronic course were statistically significant (P ! .001). Our data show that the number of IFN-g–producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infection. [validation ref - 6] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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