Detail CTL Responses of HLA-A2.1-Transgenic Mice Specific for Hepatitis C Viral Peptides Predict Epitopes for CTL of Humans Carrying HLA-A2.1 (from The Journal of Immunology 1995, 154, 2733-2342) Bibliografi Author: Shirai, Matsunori ; Arichi, Tatsumi ; Nishioka, Mikio ; Nomura, Tsutomu ; Ikeda, Kazuma ; Kawanishi, Koichi ; Engelhard, Victor H. ; Feinstone, Stephen M. ; Berzofsky, Jay A. Topik: HCV; Hepatitis C; CTL; Validation ref - 6 Bahasa: (EN )     Penerbit: American Association of Immunologists     Tempat Terbit: Bethesda    Tahun Terbit: 1995     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 10.0000@www.jimmunol.org@154@6@2733.pdf (1.54MB; 0 download) Abstract Vaccine development in animal models depends on ability to recognize epitopes seen by human T cells. In this work, we show that CTL responses in transgenic mice expressing human HLA-A2.1 prospectively predict the same four of 11 hepatitis C virus (HCV) structural protein-derived peptides, expressing a sequence motif for HLA-A2.1 binding, that are actually recognized by human A2.1-restricted CTLs. The CTLs also recognized targets endogenously expressing these proteins, Human CTLs from HCV-infected patients, tested by using the same peptides, revealed a virtually identical response repertoire. A highly conserved HCV core peptide was the most immunogenic, and may be a valuable component of a vaccine against a broad range of HCV isolates in HLA-A2-positive patients. These results suggest that, in spite of species differences, the T cell repertoire is plastic enough to allow a similar response when the same class I MHC molecule is presenting the peptide. Thus, the HLA molecule plays the primary role in determining which peptides are recognized by CTLs. This transgenic mouse model is important for the study of HLA-restricted CTL determinants and for an approach to design a potential HCV vaccine. [validation ref - 6] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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