Detail Magnitude of CD8+ T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection (from Hepatology Research 2009, 39, 256-265) Bibliografi Author: Doi, Hiroyoshi ; Hiroishi, Kazumasa ; Shimazaki, Tomoe ; Eguchi, Junichi ; Baba, Toshiyuki ; Ito, Takayoshi ; Matsumura, Takuya ; Nozawa, Hisako ; Morikawa, Kenichi ; Ishii, Shigeaki ; Hiraide, Ayako ; Sakaki, Masashi ; Imawari, Michio Topik: Acute hepatitis C; CD8+ T-cell response; Cytotoxic T lymphocyte; ELISpot assay; Hepatitis C virus; Interferon therapy; Validation ref - 40 Bahasa: (EN )     Penerbit: The Japan Society of Hepatology     Tahun Terbit: 2009     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: doi2009.pdf (209.35KB; 0 download) Abstract Aim: We investigated the relationship between the magnitude of comprehensive hepatitis C virus (HCV)-specific CD8+ T-cell responses and the clinical course of acute HCV infection. Methods: Six consecutive patients with acute HCV infection were studied. Analysis of HCV-specific CD8+ T-cell responses was performed using an interferon-g-based enzyme-linked immunospot assay using peripheral CD8+ T-cells, monocytes and 297 20-mer synthetic peptides overlapping by 10 residues and spanning the entire HCV sequence of genotype 1b. Results: Five patients presented detectable HCV-specific CD8+ T-cell responses against a single and different peptide, whereas 1 patient showed responses against three different peptides. Neither the magnitude of HCV-specific CD8+ T-cell responses nor the severity of hepatitis predicts the outcome of acute hepatitis. The maximum number of HCV-specific CD8+ T-cells correlated with maximum serum alanine aminotransferase level during the course (r = 0.841, P = 0.036). Conclusions: HCV-specific CD8+ T-cell responses were detectable in all 6 patients with acute HCV infection, and 6 novel HCV-specific CTL epitopes were identified. Acute HCV infection can resolve with detectable HCV-specific CD8+ T-cell responses, but without development of antibody against HCV. [validation ref - 40] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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